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Shire Global

Areas of Focus

Neuroscience

ADHDFor more than two decades, Shire has demonstrated leadership in neuroscience through helping more patients, progressing our pipeline, and expanding into additional conditions. Misunderstanding of conditions like Attention-Deficit/Hyperactivity Disorder (ADHD), Binge Eating Disorder (B.E.D.), and epilepsy is widespread, which can add to the unique challenges people living with these conditions are already facing. Building awareness and understanding can remove some of the additional obstacles these people may encounter.

We’ve built relationships with patient advocacy groups and organizations globally, and regularly share our expertise with physicians, patients, caregivers, and policymakers to raise awareness and broaden understanding of these conditions worldwide. We are also committed to helping combat the misuse, abuse, and diversion of ADHD medicines.

Our neuroscience division currently champions for the patients, parents, caregivers, and physicians who are touched by:

ADHD

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that manifests as a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development. It is a diverse condition that can have a significant impact on patients’ lives.5,6 ADHD is relatively common and often persists into adulthood.7,8,9,10 Only a trained healthcare professional can diagnose ADHD.

Once thought of as a childhood problem, ADHD persists into adulthood in 50-60% of people diagnosed as a child11,12,13,14 and affects around one in 30 (3.4%) adults worldwide.14

Binge Eating Disorder

Binge Eating Disorder, or B.E.D., is a distinct medical condition recognized by the American Psychiatric Association.1 In the U.S., it’s more common than anorexia and bulimia combined,2,3* affecting an estimated 2.8 million adults.2,4† Although B.E.D. affects both men and women,2 research shows that twice as many women are affected.

Epilepsy

Epilepsy is a condition characterized by recurrent epileptic seizures that aren’t provoked by an immediate identifiable cause.

References

       *   Estimated 12-month and lifetime prevalence based on a national survey of U.S. Adults at least 18 years of age
       †  Estimated 12-month prevalence in a survey of U.S. adults at least 18 years of age, extrapolated to the full U.S.
   population at least 18 years of age
  1. American Psychiatric Association. Binge-eating disorder. In: Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association; 2013:350-353.
  2. Hudson JI, Hiripi E, Pope HG Jr, Kessler RC. [Published correction appears in Biol Psychiatry. 2012;72(2):164.] Biol Psychiatry. 2007;61(3):348-358.
  3. Kessler RC, Berglund PA, Chiu WT, et al. Biol Psychiatry. 2013;73(9):904-914.
  4. Howden LM, Meyer JA. US Census Bureau Age and Sex Composition: 2010. US Census Bureau. May 2011.
  5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. eds. 2013.
  6. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders. Available at:www.who.int/entity/classifications/icd/en/bluebook.pdf. Last updated 1993; 1: 1-263. Accessed September 2017.
  7. Fayyad J, De Graaf R, Kessler R, Alonso J, Angermeyer M, Demyttenaere K, De Girolamo G, Haro JM, Karam EG, Lara C, Lépine JP, Ormel J, Posada-Villa J, Zaslavsky AM, Jin R. Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry 2007; 190: 402-409.
  8. Lara C, Fayyad J, De Graaf R, Kessler RC, Aguilar-Gaxiola S, Angermeyer M, Demytteneare K, De Girolamo G, Haro JM,
  9. Jin R, Karam EG, Lépine JP, Mora ME, Ormel J, Posada-Villa J, Sampson N. Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey Initiative. Biol Psychiatry 2009; 65: 46-54.
  10. Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med 2006; 36: 159-165.
  11. Lara C, et al. Childhood Predictors of Adult Attention-Deficit/Hyperactivity Disorder: Results From The World Health Organization World Mental Health Survey Initiative. Biological Psychiatry 2009; 65:46-54.
  12. Faraone SV, et al. The Age-Dependent Decline of Attention Deficit Hyperactivity Disorder: A Meta-Analysis of Follow-Up Studies. Psychological Medicine 2006; 36:159-165.
  13. Barklay RA, et al. The Persistence of Attention-Deficit/Hyperactivity Disorder into Young Adulthood as A Function of Reporting Source and Definition of Disorder. Journal of Abnormal Psychology 2002; 111:279-289.
  14. Ebejer JL, et al. Attention Deficit Hyperactivity Disorder in Australian Adults: Prevalence, Persistence, Conduct Problems and Disadvantage. PLoS One 2012; 7:e47404.

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