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Hypoparathyroidism is a rare, complex condition in which your parathyroid glands are either absent or damaged and cannot produce any or sufficient amounts of parathyroid hormone, also known as PTH.

Because PTH plays a central role in regulating the calcium in your body, people with Hypoparathyroidism are at risk for hypocalcemia (low blood calcium) and other chemical imbalances that must be carefully managed to help reduce the risk of serious short- and long-term health problems.[1],[2]

Compromised PTH function can interfere with the body's ability to achieve calcium balance, which may impact various organs within the body and cause low blood calcium.[3] People with Hypoparathyroidism who lack adequate PTH experience a range of symptoms related to the absorption and excretion of calcium.[4]

There are many causes of Hypoparathyroidism, ranging from past surgery to inherited parathyroid disorders, but a small percentage of patients will be classified as having idiopathic Hypoparathyroidism, which means that the cause is undetermined.[5] Understanding the cause of your Hypoparathyroidism is important for managing your disorder and your life.

Estimates suggest that chronic Hypoparathyroidism affects approximately 58,000 insured patients in the U.S.[6]

Resources and Organizations

The following organizations may be a resource for information and support for patients, families, and caregivers.* 

HypoparathyroidismAssociationInc Hypoparathyroidism Association, Inc.

Works to improve the lives of those touched by hypoparathyroidism through awareness and support.

EURORDIS Voice of Rare Disease Patients in Europe

EURODIS is a global, patient-driven alliance of over 600 rare disease patient organizations.

NORD National Organization for Rare Disorders

NORD is a US-based federation of health organizations dedicated to helping people with rare diseases.

PARADIGHM Registry for Patients with Chronic Hypoparathyroidism

Shire is proud to sponsor PARADIGHM, a long-term initiative characterizing the impact of Hypoparathyroidism.


  1. Fong J, Khan A. Hypocalcemia: Updates in diagnosis and management for primary care. Canadian Family Physician. 2012;58(2):158-162. Available at:
  2. Shoback D. Hypoparathyroidism. N Engl J Med 359;4. 2008
  3. Calcium Fact Sheet for Consumers.  National Institutes of Health Office of Dietary Supplements. Available at:
  4. Shoback D. Hypoparathyroidism. N Engl J Med 359;4. 2008
  5. Bilezikian, John P., et al. Hypoparathyroidism in the Adult: Epidemiology, Diagnosis, Pathophysiology, Target-organ Involvement, Treatment, and Challenges for Future Research. J Bone Miner Res 26.10: 2317-337. 2011
  6. Powers et al. Prevalence and Incidence of Hypoparathyroidism in the USA Using a Large Claims Database. J Bone Miner Res. 2013 DOI 10.1002/jbmr.2004.

*Shire provides funding to the above organizations in support of efforts that include, but are not limited to, research, education, meetings/events, and patient support.

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