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Director/PDMR Shareholding

March 31, 2016 – Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Ordinary Shares (“Shares”) and American Depositary Shares (“ADSs”) in the Company, as set out below, have been acquired today for the Non-Executive Directors, being the part of their total fees that are paid in shares for the period of service from January 1 to March 31, 2016.

Type of Security (1)

Number of Shares/ADSs

Dominic Blakemore

Shares

150

Olivier Bohuon

Shares

133

William Burns

Shares

176

Dr. Steven Gillis

ADSs

57

Dr. David Ginsburg

ADSs

54

David Kappler

Shares

166

Susan Kilsby

ADSs

167

Sara Mathew

ADSs

53

Anne Minto

Shares

170

(1) One ADS is equal to three Shares.

The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ respectively at £39.0774 per Share and $168.9564 per ADS.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure Rules and Transparency Rules.

Oliver Strawbridge
Senior Assistant Company Secretary

For further information please contact:

Investor Relations

Sarah Elton-Farr

seltonfarr@shire.com

+44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.

www.shire.com

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