Summary consolidated statements of cash flows

in millions of US dollars

  12 months to
December 31,
2008
$'M
12 months to
December 31
2007
$'M
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income/(loss) 156.0 (1,451.8)
Adjustments to reconcile net income/(loss) to net cash provided by operating activities:    
Loss from discontinued operations 17.6 -
Depreciation and amortization 202.9 158.3
Share-based compensation 65.2 75.2
In-process R&D charge 128.1 1,866.4
Interest on building financing obligation and amortization of deferred financing charges 8.3 12.4
Impairment of intangible assets, long-lived assets and available-for-sale securities 157.3 5.2
Gain on sale of product rights and long-term assets (30.8) (127.5)
Movement in deferred taxes 74.0 (25.4)
Equity in earnings of equity method investees (2.4) (1.8)
Minority interest (3.6) -
Changes in operating assets and liabilities, (net of acquisitions), return on investment    
in joint venture and cash used by discontinued operations 27.5 (36.3)
Net cash provided by operating activities 800.1 474.7
CASH FLOWS FROM INVESTING ACTIVITIES:    
Movements in short-term investments - 55.8
Movements in restricted cash 10.3 (9.7)
Purchases of subsidiary undertakings and long-term investments (501.6) (2,582.8)
Payment on settlement of TKT appraisal rights litigation (419.9) -
Purchases of property, plant and equipment and intangible assets (261.0) (169.4)
Proceeds from sale of long-term investments, property, plant and equipment and product rights 17.1 235.7
Returns from equity investments 0.6 2.3
Net cash used in investing activities (1,154.5) (2,468.1)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from drawings under bank facility 190.0 1,300.0
Repayment of drawings under bank facility (190.0) (1,300.0)
Proceeds from issue of 2.75% Convertible Bonds due 2014 - 1,100.0
Redemption of New River convertible notes - (279.4)
Proceeds from exercise of New River purchased call option - 141.8
Payment of debt arrangement and issuance costs - (32.8)
Building finance obligations, net 9.5 -
Proceeds from exercise of options and warrants 11.4 43.4
(Costs)/proceeds from issue of common stock, net (5.6) (877.3)
Payments to acquire treasury stock (146.6) (186.0)
Payment of dividends (46.8) (41.3)
Net cash (used in)/provided by financing activities (178.1) 1,623.0
     
Effect of foreign exchange rate changes on cash and cash equivalents (11.8) 6.0
Net decrease in cash and cash equivalents (544.3) (364.4)
Cash and cash equivalents at beginning of period 762.5 1,126.9
Cash and cash equivalents at end of period 218.2 762.5