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01 Nov 2010
Total Voting Rights

November 1, 2010 - Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, in accordance with DTR 5.6.1 of the FSA’s Disclosure and Transparency Rules, notifies the market of the following:

At close of business on October 29, 2010, Shire plc's issued voting share capital consisted of 562,177,929 ordinary shares with a nominal value of 5 pence. Each ordinary share carries one voting right. Shire plc does not hold any shares in Treasury.

The above figure (562,177,929) may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, Shire plc under the FSA's Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary


For further information please contact:

Investor Relations
Eric Rojas
+1 781 482 0999


Notes to editors


Shire’s strategic goal is to become the leading specialty biopharmaceutical company that focuses on
meeting the needs of the specialist physician. Shire focuses its business on attention deficit
hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as
well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire’s
in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong
intellectual property protection and global rights. Shire believes that a carefully selected and
balanced portfolio of products with strategically aligned and relatively small-scale sales forces will
deliver strong results.

For further information on Shire, please visit the Company’s website:

01 Nov 2010 Total Voting Rights (17KB PDF)

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